Lapis and Blue Aventurine necklace. Sterling Silver. lazuli to create a starry sky effect in the Sistine Chapel. The stone was also treasured by other ancient civilizations, such as the Mesopotamians, who used it in seals and cylinder seals. Its deep blue color symbolized royalty and divinity, and it was believed to have protective and healing properties. Lapis lazuli's historical significance as a precious gemstone and artistic material continues to captivate people to this day.